Disseminated intravascular coagulation: epidemiology, biomarkers, and management

نویسندگان

چکیده

Disseminated intravascular coagulation (DIC) is a systemic activation of the system, which results in microvascular thrombosis and, simultaneously, potentially life-threatening haemorrhage attributed to consumption platelets and factors. Underlying conditions, e.g. infection, cancer, or obstetrical complications are responsible for initiation propagation DIC process. This review provides insights into epidemiology current understanding its pathophysiology. It details use diagnostic biomarkers, recommendations from international medical societies, it an overview emerging prognostic biomarkers. Last, guidance on management. concluded that timely accurate diagnosis underlying condition essential prognosis. Treatment should primarily focus cause supportive treatment be individualised according aetiology, patient’s symptoms laboratory records.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Supportive management strategies for disseminated intravascular coagulation

Disseminated intravascular coagulation (DIC) is a syndrome characterised by the systemic activation of blood coagulation, which generates intravascular fibrin leading to thrombosis of smalland medium-sized vessels and eventually contributes to organ dysfunction (1). In addition, the consumption of platelets and coagulation factors may predispose patients with DIC to haemorrhagic complications. ...

متن کامل

Disseminated Intravascular Coagulation

EVIDENCE DEFINITIONS  Class I: Prospective randomized controlled trial.  Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies.  Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion.  Technology assessment: A technology study which doe...

متن کامل

Disseminated intravascular coagulation.

OBJECTIVES To provide an overview of the pathophysiology, manifestations, diagnosis, and treatment of disseminated intravascular coagulation (DIC) as it occurs in cancer. DATA SOURCES Published articles, research reports, and book chapters. CONCLUSIONS The syndrome of DIC is a serious hypercoagulation state that in its acute form may be life-threatening. The hemorrhage and intravascular coa...

متن کامل

[Disseminated intravascular coagulation].

The diagnosis of disseminated intravascular coagulation associated with intracranial pathology is discussed. This pathological entity is characterized by a diffuse bleeding diathesis. Laboratory studies suggest a consumption of all clotting and fibrinolytic factors with an elevation of fibrin split products as a sign of the fibrinolytic activity. The treatment consists of the administration of ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: British Journal of Haematology

سال: 2021

ISSN: ['0007-1048', '1365-2141']

DOI: https://doi.org/10.1111/bjh.17172